Denigrins A–C: new antitubercular 3,4-diarylpyrrole alkaloids from <i>Dendrilla nigra</i>
Muthyala Murali Krishna Kumar
Jarpula Devilal Naik
Kancherla Satyavathi
Hechhu Ramana
Pemmadi Raghuveer Varma
Kurre Purna Nagasree
Desaraju Smitha
Desaraju Venkata Rao
10.6084/m9.figshare.969639.v2
https://tandf.figshare.com/articles/journal_contribution/Denigrins_A_C_new_antitubercular_3_4_diarylpyrrole_alkaloids_from_i_Dendrilla_nigra_i_/969639
<div><p>Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge <i>Dendrilla nigra</i> on bioactivity-guided screening yielded three new compounds denigrins A–C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4 μg/mL) against <i>Mycobacterium tuberculosis</i> H37Rv.</p></div>
2014-05-09 09:16:27
denigrins
antitubercular
alkaloids