10.6084/m9.figshare.9730697.v1 Ko Harada Ko Harada Yoshihisa Hanayama Yoshihisa Hanayama Mikako Obika Mikako Obika Koichi Itoshima Koichi Itoshima Ken Okada Ken Okada Fumio Otsuka Fumio Otsuka Clinical relevance of insulin-like growth factor-1 to cardiovascular risk markers Taylor & Francis Group 2019 Insulin-like growth factor-1 somatopause anemia inflammatory markers fibrin-related markers 2019-08-26 09:04:32 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Clinical_relevance_of_insulin-like_growth_factor-1_to_cardiovascular_risk_markers/9730697 <p>Insulin-like growth factor-1 (IGF-1) is an anabolic hormone, the levels of which decline with age. The present study aimed to determine the impact of age-related declines in serum IGF-1 levels on various physiological processes.</p> <p>We retrospectively reviewed the medical records of patients whose serum IGF-1 levels were estimated in our department, and assessed the relationships between serum IGF-1 levels and various physiological parameters.</p> <p>A total of 427 patients with a mean (± standard deviation) age of 52.8 (± 17.1) years were included in the analysis. The levels of serum IGF-1 showed significant positive correlation with those of hemoglobin and hematocrit, and negative correlation with the presence of inflammatory and fibrin-related markers including C-reactive protein (CRP) and procalcitonin (PCT), and D-dimer and fibrin degradation products (FDP). These tendencies persisted after exclusion of patients with pituitary disease.</p> <p>In this study population of diverse diseases and backgrounds, a decline in serum IGF-1 levels with age was associated with an increase in inflammatory and fibrin-related markers. This may explain the correlation between low serum IGF-1 levels and an increased risk of cardiovascular events. Our findings suggest that serum IGF-1 is a clinically relevant marker of cardiovascular risk, particularly in males.</p>