Jatrophacine, a 4,5-<i>seco</i>-rhamnofolane diterpenoid with potent anti-inflammatory activity from <i>Jatropha curcas</i> Hu Yang Zhao Huimin Yang Aiping Lv Qi Ding Ning Lu Tu-Lin Hu Lihong Xiachang Wang 10.6084/m9.figshare.9771692.v1 https://tandf.figshare.com/articles/journal_contribution/Jatrophacine_a_4_5-_i_seco_i_-rhamnofolane_diterpenoid_with_potent_anti-inflammatory_activity_from_i_Jatropha_curcas_i_/9771692 <p>A new diterpenoid named jatrophacine (<b>1</b>), with an unusual 4,5-<i>seco</i>- rhamnofolane skeleton, was isolated from the roots of <i>Jatropha curcas</i>, together with eleven known diterpenoids. The structure of the new compound was elucidated through a detailed analysis of its 1 D- and 2 D-NMR spectra. The X-ray structure of jatrophol (<b>2</b>) is also presented. Anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that compound <b>1</b> strongly inhibited the production of nitric oxide (IC<sub>50</sub> = 0.53 μM).</p> 2019-09-05 08:41:16 Jatropha curcas Euphorbiaceae Rhamnofolane diterpenoid Jatrophacine Anti-inflammatory