Gephyyamycin and cysrabelomycin, two new angucyclinone derivatives from the <i>Streptomyces</i> sp. HN-A124
Biao Zhou
Yuan-Yuan Ji
Hao-Jian Zhang
Li Shen
10.6084/m9.figshare.9778433.v1
https://tandf.figshare.com/articles/journal_contribution/Gephyyamycin_and_cysrabelomycin_two_new_angucyclinone_derivatives_from_the_i_Streptomyces_i_sp_HN-A124/9778433
<p>Gephyyamycin (<b>1</b>) owned the rare 3,12a-epoxybenz[<i>a</i>]anthracene ring system, and cysrabelomycin (<b>2</b>) possessed an acetylated cysteine group, two new angucyclinone derivatives were isolated from the rice solid fermentation of the marine-derived <i>Streptomyces</i> sp. HN-A124, an actinobacterium isolated from the marine sediments collected from Hainan Province, China. Their structures were elucidated on the basis of MS, NMR spectroscopic, X-ray diffration data analyses and quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound <b>2</b> appeared to show moderate cytotoxicity against human prostate cancer PC3 and human ovarian carcinoma A2780 cell lines with IC<sub>50</sub> values of 19.39 and 10.23 μM, respectively; on the other hand, compound <b>2</b> also exhibited moderate antibacterial activities against <i>Staphylococcus aureus</i> and <i>Candida albicans</i> with an MIC value of 20.0 and 20 μM, respectively.</p>
2019-09-06 12:46:28
Angucyclinones
gephyromycins
X-ray diffraction
cytotoxicity