10.6084/m9.figshare.9803867.v1 Kajal Chakraborty Kajal Chakraborty Soumya Salas Soumya Salas First report of antioxidant 1<i>H</i>-benzochromenone from muricid gastropod <i>Chicoreus ramosus</i> as dual inhibitors of pro-inflammatory 5-lipoxygenase and carbolytic enzymes Taylor & Francis Group 2019 Gastropod mollusk Chicoreus ramosus 1H-benzochromenone derivative pro-inflammatory 5-lipoxygenase carbolytic enzymes anti-diabetic and anti-inflammatory 2019-09-11 11:19:36 Journal contribution https://tandf.figshare.com/articles/journal_contribution/First_report_of_antioxidant_1_i_H_i_-benzochromenone_from_muricid_gastropod_i_Chicoreus_ramosus_i_as_dual_inhibitors_of_pro-inflammatory_5-lipoxygenase_and_carbolytic_enzymes/9803867 <p>Chromene derivatives with manifold structural framework and pharmacological properties were ubiquitous in the mollusks of marine origin. A previously undescribed 1<i>H</i>-benzochromenone was isolated through bioassay-guided chromatographic purification of the organic extract of the marine gastropod mollusk <i>Chicoreus ramosus</i>. The compound was characterised as 6-(2′,2′-dimethyl)-3′-en-1′-yl-1′-oxy)-3-hydroxy-1<i>H</i>-benzo[c]chromene-2(10a<i>H</i>)-one based on integrated spectroscopic analysis. The antioxidant studies by employing the stable free radicals reported that the antioxidant activity (IC<sub>50</sub> 1.4–1.6 mM) was comparable to <i>α</i>-tocopherol (IC<sub>50</sub> 1.4–1.7 mM). The attenuating potential of the studied compound against pro-inflammatory 5-lipoxygenase (IC<sub>50</sub> 2.12 mM) was significantly greater than that exhibited by anti-inflammatory drug ibuprofen (IC<sub>50</sub> 4.4 mM), whereas its inhibitory properties against carbolytic <i>α</i>-amylase (IC<sub>50</sub> ∼0.72 mM) was comparable with that displayed by acarbose (IC<sub>50</sub> 0.43 mM). The present study recognised the potential of 1<i>H</i>-benzochromenone derivative isolated from <i>C. ramosus</i> as important pharmaceutical lead with anti-diabetic and anti-inflammatory potentials to reduce the risk of hyperglycaemia and inflammatory pathologies.</p> <p></p>