10.6084/m9.figshare.985573.v2 Rashid N. Nadaf Rashid N. Nadaf Dave G. Seapy Dave G. Seapy Palladium-Catalyzed Cross-Coupling Reactions of Potassium N-Methyltrifluoroborate Isoindolin-1-one with Aryl and Heteroaryl Chlorides Taylor & Francis Group 2014 palladium-catalyzed cross-coupling reactions potassium n-methyltrifluoroborate aryl heteroaryl chlorides isoindolin-1-one 2014-06-09 18:53:22 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Palladium_Catalyzed_Cross_Coupling_Reactions_of_Potassium_N_Methyltrifluoroborate_Isoindolin_1_one_with_Aryl_and_Heteroaryl_Chlorides/985573 <div><p></p><p>Potassium <i>N</i>-methyltrifluoroborate isoindolin-1-one was synthesized and used in Suzuki–Miyaura palladium-catalyzed cross-coupling reactions with aryl and heteroaryl chlorides to prepare 29 examples of substituted <i>N</i>-benzyl isoindolin-1-ones. The new approach benefits from mild reaction conditions that tolerate a variety of functional groups. In addition, because of the large number of commercially available aryl and heteroaryl chlorides that can serve as coupling partners, the approach readily provides access to libraries of substituted <i>N</i>-benzyl isoindolin-1-ones.</p> </div>