Efficient and Convenient Protocol for the Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using HClO<sub>4</sub>-SiO<sub>2</sub> as a Heterogeneous Recyclable Catalyst Ramu Tadikonda Mangarao Nakka Mahaboob Basha Gajula Srinuvasarao Rayavarapu Padma Rao Gollamudi Siddaiah Vidavalur 10.6084/m9.figshare.985579.v2 https://tandf.figshare.com/articles/journal_contribution/Efficient_and_Convenient_Protocol_for_the_Synthesis_of_3_5_Disubstituted_1_2_4_Oxadiazoles_Using_HClO_sub_4_sub_SiO_sub_2_sub_as_a_Heterogeneous_Recyclable_Catalyst/985579 <div><p></p><p>Silica-supported perchloric acid (HClO<sub>4</sub>-SiO<sub>2</sub>) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.</p> </div> 2014-05-29 20:31:08 convenient synthesis heterogeneous recyclable catalyst