10.6084/m9.figshare.9948065.v2
Sameh Aoun
Sameh
Aoun
Haythem Bennour
Haythem
Bennour
A novel hydroxy-bisphosphonic acid prodrug as a candidate for the delivery of ibuprofen to bone
Taylor & Francis Group
2019
Arbuzov reaction
bone inflammation
carboxylic acid
drug delivery
hydroxy-bisphosphonic acid
prodrug
2019-11-04 21:53:00
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/A_novel_hydroxy-bisphosphonic_acid_prodrug_as_a_candidate_for_the_delivery_of_ibuprofen_to_bone/9948065
<p>Active targeting with controlled delivery of anti-inflammatory drugs to the bone is not sufficiently explored. In this study, concise and novel synthesis of a hydroxy-bisphosphonic acid (HBPA) prodrug containing ibuprofen is described. The key step consisted of preparing the HBPA function from a carboxylic acid precursor, in mild conditions and using appropriate Arbuzov reactions with tris(trimethylsilyl)phosphite. This prodrug would be an excellent candidate for the treatment of bone inflammation diseases such as rheumatoid arthritis.</p>