10.6084/m9.figshare.9948065.v2 Sameh Aoun Sameh Aoun Haythem Bennour Haythem Bennour A novel hydroxy-bisphosphonic acid prodrug as a candidate for the delivery of ibuprofen to bone Taylor & Francis Group 2019 Arbuzov reaction bone inflammation carboxylic acid drug delivery hydroxy-bisphosphonic acid prodrug 2019-11-04 21:53:00 Journal contribution https://tandf.figshare.com/articles/journal_contribution/A_novel_hydroxy-bisphosphonic_acid_prodrug_as_a_candidate_for_the_delivery_of_ibuprofen_to_bone/9948065 <p>Active targeting with controlled delivery of anti-inflammatory drugs to the bone is not sufficiently explored. In this study, concise and novel synthesis of a hydroxy-bisphosphonic acid (HBPA) prodrug containing ibuprofen is described. The key step consisted of preparing the HBPA function from a carboxylic acid precursor, in mild conditions and using appropriate Arbuzov reactions with tris(trimethylsilyl)phosphite. This prodrug would be an excellent candidate for the treatment of bone inflammation diseases such as rheumatoid arthritis.</p>