A concise synthesis of peramine, a metabolite of endophytic fungi

The total synthesis of peramine, a natural product isolated from an endophytic fungi, has been achieved in four steps and 34% overall yield from known compounds. The key step was the one-pot construction of the pyrrolopyrazinone ring from pyrrole amide and propargyl bromide. The preparation of peramine-d₄ as an internal standard for quantitative analysis by MS is also described.

Peramine, a natural product isolated from an endophytic fungi, was synthesized in four steps by one-pot construction of the pyrrolopyrazinone ring as a key step.