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A facile and efficient approach for the synthesis of 3-arylthiazol-2(3H)-one

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journal contribution
posted on 2019-05-16, 13:35 authored by Yue Zhu, Qilin Wang, Haofan Luo, Zijuan Wang, Guolin Zhang, Yongping Yu

A facile and efficient method for synthesis of 3-arylthiazol-2(3H)-one through the reaction of acyl azide and 1,4-dithiane-2,5-diol was reported. This reaction proceeded at 80 °C at first and then in acidic condition at room temperature, to afford products in good yields for a wide range of substrates and a possible mechanism has also been proposed.

Funding

This project was supported from Zhejiang Provincial Natural Science Foundation of China [LY16H300001] to G. Zhang; National Natural Science Foundation of China [No. 81673291 and 81473074], and Osteoporosis & Breast Cancer Research Center, U.S.A. to Y. Yu.

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