A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides

<p>A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[3,4-b]quinoline-1,3-diones in the presence of an Et<sub>3</sub>N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series <b>9a–g</b> was evaluated for <i>in vitro</i> antibacterial activity against (+ve bacteria) <i>Staphylococcus aureus</i> ATCC 25923 and <i>Enterococcus faecalis</i> ATCC 29212, (−ve bacterium) <i>Escherichia coli</i> ATCC 25922. <i>In vitro</i> minimum inhibitory concentration (MIC) evaluations showed that the compound <b>9a</b> was effective against <i>E. coli</i> (MIC: 0.25 mg/mL) <i>S. aureus</i> (MIC: 0.25 mg/mL) and <i>E. faecalis</i> (MIC: 0.5 mg/mL).</p>