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A new androstanoid metabolite from a soil fungus Curvularia borreriae strain HS-FG-237

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posted on 28.12.2016 by Li-Fei Liu, Hui Zhang, Huan Qi, Xiao-Ming Wang, Ji-Dong Wang, Gui-Shan Tan

A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cells by CCK-8 assay and weak anti-inflammatory activity in an ANA-1 murine macrophages model.

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