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A new bischromanone from the stems of Semecarpus caudata

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journal contribution
posted on 09.11.2017 by Phu H. Dang, Tinh T. Nguyen, Tho H. Le, Hai X. Nguyen, Mai T. T. Nguyen, Nhan T. Nguyen

From an CHCl3-soluble fraction of the stems of Semecarpus caudata, one new bischromanone named semecarpanone (1), together with 5 known flavonoids (26) were isolated. Their structures were elucidated based on interpretation of spectroscopic data. The stereo-configuration of 1 was identified based on the calculated and experimental coupling constants. Compounds 46 showed potent tyrosinase inhibitory activity with the IC50 values ranging from 15.0 to 76.3 μM.