A new bischromanone from the stems of Semecarpus caudata

Dang, Phu H.; Nguyen, Tinh T.; Le, Tho H.; Nguyen, Hai X.; T. T. Nguyen, Mai; Nguyen, Nhan T.

doi:10.6084/m9.figshare.5584243.v1

gnpl_a_1399391_sm9119.pdf (597.34 kB)

A new bischromanone from the stems of Semecarpus caudata

journal contribution

posted on 2017-11-09, 07:16 authored by Phu H. Dang, Tinh T. Nguyen, Tho H. Le, Hai X. Nguyen, Mai T. T. Nguyen, Nhan T. Nguyen

From an CHCl₃-soluble fraction of the stems of Semecarpus caudata, one new bischromanone named semecarpanone (1), together with 5 known flavonoids (2–6) were isolated. Their structures were elucidated based on interpretation of spectroscopic data. The stereo-configuration of 1 was identified based on the calculated and experimental coupling constants. Compounds 4–6 showed potent tyrosinase inhibitory activity with the IC₅₀ values ranging from 15.0 to 76.3 μM.