A new diketopiperazine from the gorgonian coral <i>Menella kanisa</i>

<div><p>Chemical investigation on the gorgonian <i>Menella kanisa</i> collected from Beibu Gulf led to the isolation of a new diketopiperazine, named menazepine A (<b>1</b>), as well as three known diketopiperazines, namely cyclo(4-hydroxyprolylleucyl) (<b>2</b>), cyclo(Pro-Leu) (<b>3</b>) and cyclo(4-hydroxyprolylphenylalanyl) (<b>4</b>). The structure of the new diketopiperazine was elucidated on the basis of extensive spectroscopic analysis and by comparing the data with those of related metabolites. Compounds <b>1</b>–<b>4</b> were also evaluated for brine shrimp lethality.</p></div>



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