A new dimeric alkylresorcinol from the stem barks of Swintonia floribunda (Anacardiaceae)

Dang, Phu H.; Nguyen, Linh T. T.; Nguyen, Hue T. T.; Le, Tho H.; V., Truong N.; Nguyen, Hai X.; Le, Nghia D.; Nguyen, Mai T. T.; Nguyen, Nhan T.

doi:10.6084/m9.figshare.7177583.v2

gnpl_a_1509329_sm0769.pdf (864.53 kB)

A new dimeric alkylresorcinol from the stem barks of Swintonia floribunda (Anacardiaceae)

Version 2 2019-08-16, 14:35

Version 1 2018-10-08, 06:45

journal contribution

posted on 2019-08-16, 14:35 authored by Phu H. Dang, Linh T. T. Nguyen, Hue T. T. Nguyen, Tho H. Le, Truong N. V. Do, Hai X. Nguyen, Nghia D. Le, Mai T. T. Nguyen, Nhan T. Nguyen

From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), one new dimeric alkylresorcinol named integracin E (1), together with 4 known compounds (2–5) were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The absolute configuration of 1 was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product. Compound 1 showed potent tyrosinase inhibitory activity with an IC₅₀ value of 48.2 μM.