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A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

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posted on 2019-05-28, 13:26 authored by Sio-Hong Lam, Shu-Duan Jian, Tsong-Long Hwang, Po-Jen Chen, Hsin-Yi Hung, Ping-Chung Kuo, Tian-Shung Wu

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Funding

This work was supported by the Ministry of Science and Technology (MOST), Taiwan; the authors are also thankful for partial financial support from Chang Gung Memorial Hospital (CMRPD1B0281∼3, CMRPF1D0442∼3, CMRPF 1F0011∼3, CMRPF1F0061∼3 and BMRP450 granted to H.-L.H).

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    Natural Product Research

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    Keywords

    Menispermaceaeanti-inflammatorysuperoxide anion generationelastase release

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    CC BY 4.0

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