A new diterpene from <i>Clinopodium chinense</i>

<div><p>A new abietane diterpene, named as 3β-hydroxy-12-<i>O</i>-β-d-glucopyranosyl-8,11,13-abietatrien-7-one (<b>1</b>), together with four known flavonoids, was isolated from the hot water extract of the aerial parts of <i>Clinopodium chinense</i>. Their structures were determined by analysing the spectroscopic data including 1D, 2D NMR and HR-ESI-MS. Compound <b>1</b> tested against HepG-2 and A549 cancer cell lines expressed weak cytotoxicity. Cardioprotective effects of compounds <b>2</b>–<b>5</b> against H<sub>2</sub>O<sub>2</sub>-induced apoptosis in H9c2 cells were also evaluated; compounds <b>2</b> and <b>3</b> exhibited moderate cardioprotective effect.</p></div>




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