gnpl_a_1547294_sm6195.pdf (563.52 kB)
A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa
journal contribution
posted on 2019-01-12, 09:32 authored by Yan-bei Tu, Tong Xiao, Gui-yi Gong, Ya-qi Bian, Yan-fang LiA new isoflavone, milletenol A (1), along with four known flavonoids (2–5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4-stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.