gnpl_a_1543683_sm5388.pdf (504.2 kB)
A new sesquiterpenoid glycoside from Saussurea involucrata
journal contribution
posted on 2019-02-14, 07:32 authored by Shizhou Qi, Yiren Yang, Xiaoyan Xian, Xianzhe Li, Huiyuan GaoSaussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7R, 8S, 11S)-11, 13-dihydrodehydrocostuslactone-8-O-6'-2''(E)-butenoyl-β-D-glucopyranoside (1), together with seven known compounds (2–8) were isolated from the dried aerial part of S. involucrata. Their structures were elucidated by spectroscopic and physico-chemical analyses. The antioxidant and anti-inflammatory activities of compound 1 were investigated. And compound 1 showed weak radical scavenging activity and low inhibitory activity on nitric oxide (NO) production.