A new sesquiterpenoid glycoside from <i>Saussurea involucrata</i>

<p><i>Saussurea involucrata</i>, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1<i>R</i>, 5<i>R</i>, 6<i>R</i>, 7<i>R</i>, 8<i>S</i>, 11<i>S</i>)-11, 13-dihydrodehydrocostuslactone-8-<i>O</i>-6'-2''(<i>E</i>)-butenoyl-<i>β</i>-D-glucopyranoside (<b>1</b>), together with seven known compounds (<b>2</b>–<b>8</b>) were isolated from the dried aerial part of <i>S. involucrata</i>. Their structures were elucidated by spectroscopic and physico-chemical analyses. The antioxidant and anti-inflammatory activities of compound <b>1</b> were investigated. And compound <b>1</b> showed weak radical scavenging activity and low inhibitory activity on nitric oxide (NO) production.</p>