gnpl_a_1613393_sm7640.pdf (487.36 kB)
A novel cytotoxic flavonoid C-glycoside from premna fulva
journal contribution
posted on 2019-05-28, 13:28 authored by Kui-Wu Wang, Sheng-Nan Yan, Ting-Ting Zhang, Hai-Jiang Zhang, Bin Wu, Hong WangPremna fulva Craib, locally known as “Zhangu” in China, is a kind of traditional medicinal plant. A phytochemical investigation on this plant led to the isolation of a novel flavonoid glycoside along with three known analogues. The chemical structure of the new compound was determined by spectral and chemical analysis as apigenin 8-C-β-D-xylopyranoside (1). Compound 1 showed weak inhibitory activities in vitro against to four tumor cell lines (HL-60, Bcap37, SMMC7721, and P388) with IC50 values of 12.58, 19.31, 31.02, and 48.19 μg/mL, respectively. The result might be helpful to explain the application of P. fulva in Traditional Chinese Medicine.