A novel sesquiterpene derivative with a seven-membered B ring from Illigera aromatica

A novel sesquiterpene derivative with a seven-membered B ring, illigerine (1), along with four known compounds, 1-epi-chiliophyllin (2), 3,4-dihydroxyphenethyl alcohol (3), coniferyl alcohol (4) and phenylpropionic acid (5), were isolated from Illigera aromatica S. Z. Huang et S. L. Mo. Their structures were identified by 1D/2D NMR, HRESIMS and electronic circular dichroism spectra and the cytotoxic activity and inhibitory effect of NO production in LPS-stimulated RAW264.7 were also evaluated. This is the first report of sesquiterpene isolated from the genus Illigera.