A rapid, mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles

Hebade, Madhav J.; Kamble, Rahul D.; Hese, Shrikant V.; Mogle, Pratima P.; Ambhore, Ajay N.; Kadam, Shuddhodan N.; Dawane, Bhaskar S.

doi:10.6084/m9.figshare.3462917.v1

gpss_a_1149851_sm8276.docx (1.58 MB)

A rapid, mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles

journal contribution

posted on 2016-06-24, 14:54 authored by Madhav J. Hebade, Rahul D. Kamble, Shrikant V. Hese, Pratima P. Mogle, Ajay N. Ambhore, Shuddhodan N. Kadam, Bhaskar S. Dawane

An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respectively. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent.