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A solvent and transition metal-free, highly efficient Brønsted acidic ionic liquid promoted one-potthree-component reactions for the synthesis of tetrasubstituted pyrroles

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posted on 02.04.2019 by Amol Balu Atar, Eunbi Han, Dae Hyup Sohn, Jongmin Kang

The present protocol describes a highly efficient, transition metal and solvent-free one-pot annulation of amines, dialkyl acetylenedicarboxylates and β-nitrostyrene using imidazolium Brønsted acidic ionic liquid for the synthesis of tetrasubstituted pyrroles. A diverse functionalized tetrasubstituted pyrroles derivatives were obtained with excellent yields under transition metal and solvent-free conditions. The Brønsted acidic ionic liquid can be easily recovered and reused for the next reaction without any effects on the yields of the products. This green protocol provides structurally complex, medicinally important tetrasubstituted pyrroles with various substitution patterns in a one-pot operation.

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This research was supported by Basic Science Research Program through the National Research Foundation of Republic of Korea (NRF) funded by the Ministry of Education, Science and Technology (2016R1D1A1B01007177).

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