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An expedient and eco-friendly approach for multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles using nano-Al2O3/BF3/Fe3O4 as reusable catalyst

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journal contribution
posted on 2019-10-29, 21:59 authored by Elaheh Babaei, Bi Bi Fatemeh Mirjalili

The pyranopyrazole derivatives have many biological activities. They were synthesized via a four-component coupling of aromatic aldehyde, malononitrile, ethyl acetoacetate and hydrazine hydrate. In this study, dihydropyrano[2,3-c]pyrazoles have been synthesized in the presence of nano-Al2O3/BF3/Fe3O4 as catalyst in water/ethanol under reflux conditions. The catalyst was removed from the mixture of reaction by an external magnet and was reusable for several times without any loss of its activity. The obtained pyranopyrazoles were characterized by various methods such as FT-IR, 1HNMR and melting point. Easy purification, clean and convenient procedure are some advantages of this method.

Funding

The Research Council of Yazd University is gratefully acknowledged for financial support of this work.

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