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An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study

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journal contribution
posted on 2019-05-08, 07:37 authored by Travis F. Henchie, Ellen M. Gravallese, Todd L. Bredbenner, Karen L. Troy

Quantifying joint deformity in people with rheumatoid (RA) and psoriatic arthritis (PsA) remains challenging. Here, we demonstrate a new method to measure bone erosions and abnormal periosteal growths, based on the difference between a predicted healthy and actual diseased joint surface. We optimized the method by creating and measuring artificial bone erosions and growths. Then we measured 46 healthy and diseased patient surfaces. We found average sensitivity errors of ≤0.27 mm when measuring artificial erosions and growths. Patients had significantly more bone erosion than healthy subjects. Surface based outcomes are a novel way to interpret and quantify bone changes in PsA and RA.

Funding

This study was funded by a Collaborative Seed Grant from the University of Massachusetts Medical School and Worcester Polytechnic Institute.

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