gnpl_a_1488706_sm3850.doc (4.36 MB)
Aspergilolide, a steroid lactone produced by an endophytic fungus Aspergillus sp. MBL1612 isolated from Paeonia ostii
journal contribution
posted on 2019-03-01, 17:22 authored by Pei-Liang Zhang, Gang Wang, Feng-Qing Xu, Jin-Song Liu, Ju-Tao Wang, Rui Zhang, Hai-Tao Liu, Jiang-Miao Hu, Guo-Kai Wang, Pei-Yun WuA new steroid lactone aspergilolide (1), and nine known compounds helvolic acid (2), verruculogen (3), tryprostatin B (4), 13-oxofumitremorgin B (5), fumitremorgin C (6), demethoxy fumitremorgin C (7), terezine D (8), aszonalenin (9), 12, 13-dihydroxy-fumitremorgin C (10) from cultures of the endophytic fungus Aspergillus sp. MBL1612. Their chemical structures were determined by a series of extensive spectroscopic methods. All of the compounds were isolated from this genus for the first time. The cytotoxicity against five human cancer cell lines of new compound were detected.