Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis

Loures, Marco Antonio Rocha; Alves, Hugo Vicentin; de Moraes, Amarilis Giaretta; da Silva Santos, Thaís; Lara, Fernanda Formaggi; Neves, Janisleya Silva Ferreira; Macedo, Luciana Conci; Juarez Vieira Teixeira, Jorge; Maria Sell, Ana; Eliete Laguila Visentainer, Jeane

doi:10.6084/m9.figshare.7624889.v1

ierm_a_1564039_sm9090.docx (1.39 MB)

Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis

journal contribution

posted on 2019-01-24, 17:33 authored by Marco Antonio Rocha Loures, Hugo Vicentin Alves, Amarilis Giaretta de Moraes, Thaís da Silva Santos, Fernanda Formaggi Lara, Janisleya Silva Ferreira Neves, Luciana Conci Macedo, Jorge Juarez Vieira Teixeira, Ana Maria Sell, Jeane Eliete Laguila Visentainer

Background: Psoriatic arthritis (PsA) is a chronic skin and joint condition that considerably affects patient quality of life. Several studies have demonstrated different associations of genetic polymorphisms in the pathogenic process of PsA. Therefore, we conducted a meta-analysis to estimate the effect of polymorphisms in the cytokines TNF, IL12B, IL23A, and IL23R on PsA risk.

Methods: We screened 1,097 abstracts and identified 14 relevant studies published between January 2007 and December 2017. A systematic search was conducted in PubMed, Web of Knowledge and Scopus databases. Meta-analyses were performed for the comparisons of alleles and multiple genetic models.

Results: Among the cytokines studied, we found 17 polymorphisms that were the most investigated. The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), −308 G > A (rs1800629), and −857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026).

Conclusion: Our findings suggest that these variant cytokine genes may strongly influence the immunological response of PsA.