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Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil

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journal contribution
posted on 08.10.2015 by Carlos Alberto Theodoro Siqueira, Alessandra Freitas Serain, Aislan Cristina Rheder Fagundes Pascoal, Nathalia Luiza Andreazza, Caroline Caramano de Lourenço, Ana Lúcia T. Góis Ruiz, João Ernesto de Carvalho, Ana Cláudia Oliveira de Souza, Juliana Tonini Mesquita, Andre Gustavo Tempone, Marcos José Salvador

Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC–MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil.