Biofunctional properties of <i>Eruca sativa</i> Miller (rocket salad) hydroalcoholic extract

<p><i>Eruca sativa</i> Miller is a worldwide common alimentary plant (rocket leaves). The aim of this study was to correlate the potential <i>in vitro</i> scavenging activity of the <i>E. sativa</i> hydroalcoholic extract (HAE) with its <i>in vivo</i> hypoglycaemic effect. In DDPH free radical (DFR) and ferric-reducing antioxidant power assays, HAE in a concentration dependent manner (25–100 μg/mL) displayed a strong scavenging activity with maximum effect of 88% and 75% at 100 μg/mL, respectively. Daily administration of HAE (50 mg/kg; p.o.) in the <i>in vivo</i> model of alloxan-induced diabetic rabbits for 28 days showed significant reduction in glycaemia, also supported by recovery of body weight. In conclusion, our results give preliminary information on the potential use of this plant as a nutraceutical, useful to control and/or prevent a hyperglycaemic status.</p>