CETP Gene may be Associated with Advanced Age-related Macular Degeneration in the Chinese Population

<div><p></p><p><i>Objectives</i>: This study aims to investigate whether variations in <i>LIPC, CETP, ABCA1</i> and <i>LPL</i>, which are involved in high-density lipoprotein (HDL) metabolism, are associated with advanced age-related macular degeneration (AMD) in the Chinese population.</p><p><i>Design and Methods</i>: A total of 119 Chinese patients with advanced AMD and 99 control individuals were recruited. Genomic DNA was extracted from peripheral blood leukocytes. Genotypes of seven single nucleotide polymorphisms (SNPs) including rs1061170 and rs1410996 in <i>CFH</i>, rs10490924 in <i>HTRA1</i>, rs10468017 in <i>LIPC</i>, rs3764261 in <i>CETP</i>, rs1883025 in <i>ABCA1</i> and rs12678919 near <i>LPL</i> were determined by polymerase chain reaction (PCR) followed by allele-specific restriction enzyme digestion or SNaPshot. Unconditional logistic regression analyses were performed to generate a risk predictive model.</p><p><i>Results</i>: We observed the frequency of allele A of rs3764261 in <i>CETP</i> to be significantly lower in advanced AMD after Bonferroni correction (15.5% in patients with AMD and 20.7% in controls; OR = 0.49, 95% CI: 0.29–0.85; <i>p</i> = 0.011). Furthermore, we found that it was also associated with reduced risk of both unilateral AMD (OR = 0.52, 95% CI: 0.28–0.98; <i>p</i> = 0.043) and bilateral AMD (OR = 0.45, 95% CI: 0.22–0.91; <i>p</i> = 0.026). Rs10468017 in <i>LIPC</i>, rs12678919 near <i>LPL</i> and rs1883025 in <i>ABCA1</i> were not found to be associated with advanced AMD (all <i>p</i> > 0.05).</p><p><i>Conclusion</i>: Our data suggested that the allele A in rs3764261 in <i>CETP</i> gene may be associated with a decreased risk of advanced AMD in Chinese population.</p></div>