Characterization and bioactive potentials of secondary metabolites from <i>Fusarium chlamydosporum</i>

<p>A search for bioactive secondary metabolites from the endophytic fungus <i>Fusarium chlamydosporum</i>, isolated from the root of <i>Suaeda glauca</i>, led to the isolation of three indole derivatives (<b>1–3</b>), three cyclohexadepsipeptides (<b>4–6</b>), and four pyrones (<b>7–10</b>). The structures of new (<b>1</b>) and known compounds (<b>2–10</b>) were elucidated on the basis of extensive spectroscopic analysis. All these compounds were evaluated for phytotoxic, antimicrobial activities, and brine shrimp lethality. Compound <b>1</b> showed significant phytotoxic activity against the radicle growth of <i>Echinochloa crusgalli</i>, even better than the positive control of 2,4-D. Cyclohexadepsipeptides (<b>4–6</b>) and pyrones (<b>7–10</b>) exhibited brine shrimp lethality, especially <b>4</b> and <b>7</b> with the LD<sub>50</sub> values of 2.78 and 7.40 μg mL<sup>−1</sup>, respectively, better than the positive control.</p>