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Chemical composition and anti-inflammatory activity of the essential oil from the leaves of Limnocitrus littoralis (Miq.) Swingle from Vietnam

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journal contribution
posted on 20.08.2019 by Tuan Quoc Doan, Duc Viet Ho, Nhan Trong Le, Anh Tuan Le, Kiem Van Phan, Hoai Thi Nguyen, Ain Raal

The oil from the leaves of Limnocitrus littoralis (Miq.) Swingle was obtained by hydrodistillation and investigated by gas chromatography combined with mass spectrometry (GC/MS), the anti-inflammatory effect of the oil was examined on a LPS-induced RAW264.7 cells. An aggregate of forty components were identified, representing 93.0% of the oil. This oil was subjugated by monoterpene hydrocarbons (27.7%), sesquiterpene hydrocarbons (32.3%) and oxygenated sesquiterpenes (4.6%). The significant constituents of L. littoralis essential oil were determined as follows; myrcene (24.9%), γ–muurolene (11.0%), and oleic acid (10.3%). The essential oil of L. littoralis showed activity against the nitric oxide (NO) generation with the IC50 value to 12.50 ± 1.19 µg/L. The anti-inflammatory effect of essential oil from the leaves of L. littoralis is reported for the first time.


We are grateful to Hue University for the financial support of this study (ID No: DHH2019-04-90).