Chemical constituents and biological activities of <i>Viburnum macrocephalum</i> f. <i>keteleeri</i>

<p>Three new compounds (<b>1</b>–<b>3</b>) and seven known compounds (<b>4</b>–<b>10</b>) have been isolated from the ethanolic extract of <i>Viburnum macrocephalum</i> f. <i>keteleeri</i> using bioactivity-guided fractionation and identified as methyl (2-<i>α</i>-L-rhamnopyranosyloxy)acetate (<b>1</b>), methyl (2<i>R</i>-3-<i>α</i>-L-rhamnopyranosyloxy)glycerate (<b>2</b>), methyl (3<i>R</i>-4-<i>α</i>-L-rhamnopyranosyloxy-3-hydroxy)butanoate (<b>3</b>), bridelionoside B (<b>4</b>), (6<i>S</i>,7<i>E</i>,9<i>R</i>)-roseoside (<b>5</b>), linarionoside A (<b>6</b>), 3,7,11-trimethyl-1,6-dodecadien-3,10,11-triol (<b>7</b>), (+)-8-hydroxylinalool (<b>8</b>), <i>β</i>-sitosterol (<b>9</b>) and daucosterol (<b>10</b>). The structures of <b>1</b>–<b>3</b>, including absolute configurations, were determined by spectroscopic data (<sup>1</sup>H and <sup>13</sup>C NMR, HSQC, HMBC and ORD) and chemical methods. In addition, compounds <b>1–8</b> were assayed for their insecticidal and antimicrobial activities. Compounds <b>7</b> and <b>8</b> exhibited moderately insecticidal effects against <i>Mythimna separata</i> with LD<sub>50</sub> values of 180 and 230 μg g<sup>−1</sup>, respectively. Compounds <b>2</b>, <b>3</b>, <b>7</b> and <b>8</b> showed varying antimicrobial activities with IC<sub>50</sub> values ranging from 125 to 529 μM.</p>