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Chemical constituents of the mangrove-associated fungus Capnodium sp. SZ-F22. A new eremophilane sesquiterpene

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journal contribution
posted on 28.11.2015 by Haibing He, Zhongjun Ma, Qianqian Wang, Yu Liu, Hualin Xu

A new eremophilane sesquiterpene, capnodiumone (1), along with five known eremophilane sesquiterpenes (2–6) and eight other compounds (7–14), have been isolated from a mangrove-associated fungus Capnodium sp. SZ-F22. The chemical structures were elucidated on the basis of extensive spectroscopic analysis. The broth extract of the fungus exhibited a good inhibitory effect on the mycelium growth against Fusarium graminearum at 100 μg/mL, however, all the 14 compounds showed no expected antifungal activity. The probable reasons were discussed.