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Circulating adiponectin as a biomarker in renal cell carcinoma: a systematic review and meta-analysis

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posted on 2019-09-19, 12:35 authored by Ning Yi Yap, Foo Ngan Yap, Komathi Perumal, Retnagowri Rajandram

Context: Metabolic imbalance in renal cell carcinoma (RCC) can lead to abnormal adiponectin levels.

Objective: To evaluate circulating adiponectin as a detection or predictive marker for RCC.

Methods: A comprehensive literature search and meta-analysis was performed on studies reporting circulating adiponectin levels and RCC. The meta-analysis was performed using RevMan.

Results: Seven studies compared the circulating adiponection levels between RCC cases and controls. Adiponectin level was significantly lower in RCC cases compared to controls at pre-diagnosis and pre-operative time-points. RCC stage, grade and subtype did not affect adiponectin levels.

Conclusion: Low circulating adiponectin could be a predictive or risk factor for RCC.

Funding

This study was partially supported by University of Malaya Research Grant RG393/17AFR.

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