Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome

Cheng, Jin M.; Oemrawsingh, Rohit M.; Akkerhuis, K. Martijn; Garcia-Garcia, Hector M.; de Boer, Sanneke P. M.; Battes, Linda C.; Buljubasic, Nermina; Lenzen, Mattie J.; de Jaegere, Peter P. T.; van Geuns, Robert-Jan; Serruys, Patrick W.; Kardys, Isabella; Boersma, Eric

doi:10.6084/m9.figshare.11807007.v1

ibmk_a_957725_sm0001.pdf (86.88 kB)

Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome

journal contribution

posted on 2020-02-05, 11:02 authored by Jin M. Cheng, Rohit M. Oemrawsingh, K. Martijn Akkerhuis, Hector M. Garcia-Garcia, Sanneke P. M. de Boer, Linda C. Battes, Nermina Buljubasic, Mattie J. Lenzen, Peter P. T. de Jaegere, Robert-Jan van Geuns, Patrick W. Serruys, Isabella Kardys, Eric Boersma

Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome.

Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma.

Results: Higher MCP-1, MIP-1α and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1α and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events.

Conclusions: RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome.

Trial registration:ClinicalTrials.gov identifier: NCT01789411.