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CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones
journal contribution
posted on 2019-07-08, 12:55 authored by Baohua Zhang, Lanxiang ShiIn a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.