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Cu2O/Cs2CO3/DMF: An efficient catalytic system for N-arylation of imidazole with aryl halides under ligand-free conditions

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journal contribution
posted on 17.07.2017 by Xiaochuang Wang, Meiji Wang, Jianwei Xie

A ligand-free Cu-catalyzed protocol for the Ullmann-type N-arylation of N-containing heterocycles with aryl or heteroaryl iodides and bromides has been established. A broad range of functional groups is well tolerated on both of the cross-coupling partners, producing the desired products in good to excellent yields.


We thank the Natural Science Foundation of China (NSFC, no. 21606153) and the Ministry of Education Innovation Team (no. IRT15R46) for the financial support for this work.