Decarboxylation of indole-3-carboxylic acids under metal-free conditions

2020-02-14T12:50:02Z (GMT) by Xia Chen Xiao-Yu Zhou

Two reaction systems have been developed for the decarboxylation of indole-3-carboxylic acids. The decarboxylation can be achieved smoothly under K2CO3-catalyzed or acetonitrile-promoted basic conditions. It provided an efficient and simple method for the transformation of indole-3-carboxylic acids and the corresponding indoles were isolated with good to excellent yields. From the experimental facts, we put forward the possible reaction mechanism.