lsyc_a_1703137_sm6584.doc (1.94 MB)
Decarboxylation of indole-3-carboxylic acids under metal-free conditions
journal contribution
posted on 2020-02-14, 12:50 authored by Xia Chen, Xiao-Yu ZhouTwo reaction systems have been developed for the decarboxylation of indole-3-carboxylic acids. The decarboxylation can be achieved smoothly under K2CO3-catalyzed or acetonitrile-promoted basic conditions. It provided an efficient and simple method for the transformation of indole-3-carboxylic acids and the corresponding indoles were isolated with good to excellent yields. From the experimental facts, we put forward the possible reaction mechanism.