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Efficacy and safety of fecal microbiota transplantation for decolonization of intestinal multidrug-resistant microorganism carriage: beyond Clostridioides difficile infection

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journal contribution
posted on 13.09.2019 by Young Kyung Yoon, Jin Woong Suh, Eun-Ji Kang, Jeong Yeon Kim

Persistent reservoirs of multidrug-resistant microorganisms (MDRO) that are prevalent in hospital settings and communities can lead to the spread of MDRO. Currently, there are no effective decolonization strategies, especially non-pharmacological strategies without antibiotic regimens. Our aim was to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for the eradication of MDRO. A systematic literature search was performed to identify studies on the use of FMT for the decolonization of MDRO. PubMed, EMBASE, Web of Science, and Cochrane Library were searched from inception through January 2019. Of the 1395 articles identified, 20 studies met the inclusion and exclusion criteria. Overall, the efficacy of FMT for the eradication of each MDRO was 70.3% (102/146) in 121 patients from the 20 articles. The efficacy rates were 68.2% (30/44) for gram-positive bacteria and 70.6% (72/102) for gram-negative bacteria. Minor adverse events, including vomiting, diarrhea, abdominal pain, and ileus, were reported in patients who received FMT. FMT could be a promising strategy to eradicate MDRO in patients. Further studies are needed to confirm these findings and establish a comprehensive FMT protocol for standardized treatment.Key messages

The development of new antibiotics lags behind the emergence of multidrug-resistant microorganisms (MDRO). New strategies are needed.

Theoretically, fecal microbiota transplantation (FMT) might recover the diversity and function of commensal microbiota from dysbiosis in MDRO carriers and help restore colonization resistance to pathogens.

A literature review indicated that FMT could be a promising strategy to eradicate MDRO in patients.

The development of new antibiotics lags behind the emergence of multidrug-resistant microorganisms (MDRO). New strategies are needed.

Theoretically, fecal microbiota transplantation (FMT) might recover the diversity and function of commensal microbiota from dysbiosis in MDRO carriers and help restore colonization resistance to pathogens.

A literature review indicated that FMT could be a promising strategy to eradicate MDRO in patients.

Funding

This research was partly supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (Ministry of Science and ICT), (No. NRF-2019R1F1A1051267), and by a grant from the Korea Health Technology R&B Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C1048). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

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