tgcl_a_1556744_sm3212.pdf (4.69 MB)
Efficient one-pot catalyst-free synthesis of novel coumarin- spiro[indoline-3,4'-pyran] conjugates via three-component domino reaction in aqueous medium
journal contribution
posted on 2018-12-12, 06:44 authored by Adil Omar, Keyume AblajanA simple, efficient, eco-friendly and catalyst-free procedure was developed for the construction of novel coumarin-spiro[indoline-3,4'-pyran] conjugates via three-component reactions of various synthetic beta-ketoesters with isatins and malononitrile in aqueous medium. In addition to operational simplicity and absence of tedious separation procedures, being catalyst–free is the prominent advantage of this method.