lsyc_a_1410894_sm1388.docx (816.92 kB)
Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis
journal contribution
posted on 2018-02-13, 16:43 authored by Dávid Illés Nagy, Alajos Grün, Krisztina Lévay, Sándor Garadnay, István Greiner, György KeglevichThe reaction of 1H-imidazol-1-ylacetic acid and two equivalents of phosphorus trichloride/phosphorous acid at 75 °C in sulfolane, or in the presence of catalytic amounts of [bmim][BF4] afforded zoledronic acid in yields up to 75%. The joint use of the ionic liquid additive and sulfolane as the solvent was synergetic affording highly valuable zoledronic acid in a record yield of 93%.