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Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation

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journal contribution
posted on 2019-08-12, 07:41 authored by Shymaa A. Abbass, Gamal A. I. Moustafa, Heba A. Hassan, Gamal El-Din A. Abuo-Rahma

We developed a facile one-pot procedure for the synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thione under ultrasonic irradiation. The method is based on a three components reaction of aldehydes, ketones, and thiourea under basic conditions affording isolated yields of up to 95% within a reaction time of 30–90 min.

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