lsyc_a_899605_sm2188.pdf (2.96 MB)
Formal Synthesis of (+)-α-Conhydrine and Stereoselective Synthesis of Pyrrolidine Analogue via the Diastereoselective Chelation-Controlled Hydride Reduction and Wittig Reaction
Version 3 2014-07-07, 22:21
Version 2 2014-07-07, 22:21
Version 1 2014-07-07, 22:21
journal contribution
posted on 2014-07-07, 22:21 authored by Tian Jin, Yu Mu, Jin-Seok Kim, Seok-Hwi Park, Xiangdan Jin, Jong-Cheol Kang, Chang-Young Oh, Won-Hun HamAsymmetric syntheses of (+)-α-conhydrine and its pyrrolidine analogue were achieved from readily available L-serine. The key step involved highly diastereoselective chelation-controlled hydride reduction of the amino ketone to give the anti-amino alcohol and Wittig reaction.