Furanocoumarins with potential antiproliferative activities from <i>Clausena lenis</i>

<p>A phytochemical investigation on the stems and leaves of <i>Clausena lenis</i> led to the isolation of a new furanocoumarin, clauselenisin A (<b>1</b>), together with five known analogues (<b>2</b>–<b>6</b>). The structure of <b>1</b> was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (<b>2</b>–<b>6</b>) were isolated from <i>C. lenis</i> for the first time. All isolated compounds were evaluated for their their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 <i>in vitro</i>. Compounds <b>1</b>–<b>6</b> showed significant antiproliferative effects with IC<sub>50</sub> values ranging from 0.36 to 16.48 μM.</p>