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HIV-1 pseudoviruses constructed in China regulatory laboratory

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posted on 2019-12-20, 14:44 authored by Jianhui Nie, Weijin Huang, Qiang Liu, Youchun Wang

To better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compared with the standard pseudovirus panels derived from other countries/regions, the Chinese isolates are more susceptible to neutralization by the sera obtained in China, revealing the strain/subtype specificity. Some of these pseudoviruses have already been used for the evaluation of HIV vaccines and drug candidates in Chinese clinical trials. The pseudoviruses panel is widely shared with interested scientists involved in the research and development of vaccines and antiviral drugs against HIV-1 strains prevalent in China.

Funding

This work was supported by the National Science and Technology Major Projects of Infectious Disease under Grants 2017ZX10201101-003-002, 2018ZX10731101-002-006, 2018ZX10731101-002-009, 2018ZX10731-101-001-006, 2012ZX10004701, and 2009ZX10004-801. The funding source had no role in the writing of the manuscript or the decision to submit the manuscript for publication.

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