ganp_a_1739662_sm8598.docx (7.7 MB)
Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum
journal contribution
posted on 2020-03-18, 13:38 authored by Xue Wang, Jia-Jia Wang, Xin-Yue Suo, Hao-Ran Sun, Bo Zhen, Hua Sun, Jian-Guang Li, Teng-Fei JiThree new polycyclic polyprenylated acylphloroglucinol derivatives, hyperacmosins H-J (1–3), with four known compounds (4–7), were isolated from the air-dried aerial parts of Hypericum acmosepalum. Especially, compounds 1 and 2 were identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). Their structures were established by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra. The hepatoprotective activity of seven compounds were evaluated. Compounds 1 and 5 exhibited hepatoprotective activity against paracetamol-induced HepG2 cell damage.