Improved Protocol for Mononitration of Phenols with Bismuth(III) and Iron(III) Nitrates

<div><p></p><p>A simple and efficient multigram procedure was developed for the selective mononitration of various activated phenols. The reaction proceeded smoothly with 0.5 equivalents of Bi(NO<sub>3</sub>)<sub>3</sub> · 5H<sub>2</sub>O or Fe(NO<sub>3</sub>)<sub>3</sub> · 9H<sub>2</sub>O in acetone at ambient temperature or at reflux. The desired products were isolated in 62–93% total yield and essentially no overnitrated compounds were detected.</p> </div>