Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

Kumarathasan, Premkumari; Vincent, Renaud; Bielecki, Agnieszka; Blais, Erica; Blank, Katrin; Das, Dharani; Karthikeyan, Subramanian; Cakmak, Sabit; Fisher, Mandy; Arbuckle, Tye; Fraser, William

doi:10.6084/m9.figshare.3153802.v1

ibmk_a_1134663_sm5780.docx (24.23 kB)

Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

journal contribution

posted on 2016-04-05, 02:32 authored by Premkumari Kumarathasan, Renaud Vincent, Agnieszka Bielecki, Erica Blais, Katrin Blank, Dharani Das, Subramanian Karthikeyan, Sabit Cakmak, Mandy Fisher, Tye Arbuckle, William Fraser

Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.

Methods and results: Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).

Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.