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Inhibition effect of phenyl compounds from the Oryza sativa roots on melanin production in murine B16-F10 melanoma cells

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Version 2 2015-04-28, 10:01
Version 1 2015-04-28, 10:01
journal contribution
posted on 2015-04-28, 10:01 authored by Jin-Gyeong Cho, Jeongran Huh, Rak-Hun Jeong, Byeong-Ju Cha, Sabina Shrestha, Dong-Geol Lee, Hee-Cheol Kang, Ji-Young Kim, Nam-In Baek

Five phenyl compounds, vanillin (1), methyl trans-ferulate (2), trans-p-coumaric acid methyl ester (3), N-benzoyltryptamine (4), and N-(trans-cinnamoyl)tryptamine (5), were isolated from the roots of Oryza sativa L. and identified on the basis of spectroscopic data. Compounds 3 and 5 showed strong inhibition effect on melanin production in murine B16-F10 melanoma cells and tyrosinase activity. Also, the quantitative analysis of the compounds was carried out using LC/MS/MS experiment. Compounds 3 and 5 could be used as skin-whitening agents.

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